2011

Cesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes risk, Bonifacio E, Warncke K, Winkler C, Wallner M, Ziegler AG. Diabetes. 2011 Dec; 60(12): 3300-6.

Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes, Pflueger M, Seppänen-Laakso T, Suortti T, Hyötyläinen T, Achenbach P, Bonifacio E, Orešič M, Ziegler AG. Diabetes. 2011 Nov; 60(11): 2740-7.

Metabolic regulation in progression to autoimmune diabetes, Sysi-Aho M, Ermolov A, Gopalacharyulu PV, Tripathi A, Seppänen-Laakso T, Maukonen J, Mattila I, Ruohonen ST, Vähätalo L, Yetukuri L, Härkönen T, Lindfors E, Nikkilä J, Ilonen J, Simell O, Saarela M, Knip M, Kaski S, Savontaus E, Orešič M. PLoS Comput Biol. 2011 Oct; 7(10): e1002257. Epub 2011 Oct 27.

Bonifacio, E, Eugster, A, and V Lampasona. "Developing and Validating High Sensitivity/Specificity Autoantibody Assays". Immunoendocrinology: Scientific and Clinical Aspects. Ed. George Einsenbarth. New York: Springer, 2011.

Smura, T, and M Roivainen."Enterovirus infection of cultured human pancreatic islets". Diabetes and Viruses. New York: Springer, in press.

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes, Brown CT, Davis-Richardson AG, Giongo A, Gano KA, Crabb DB, Mukherjee N, Casella G, Drew JC, Ilonen J, Knip M, Hyöty H, Veijola R, Simell T, Simell O, Neu J, Wasserfall CH, Schatz D, Atkinson MA, Triplett EW. PLoS One. 2011; 6(10): e25792. Epub 2011 Oct 17.

Comparative evaluation of simple indices of graft function after islet transplantation, Caumo A, Maffi P, Nano R, Luzi L, Hilbrands R, Gillard P, Jacobs-Tulleneers-Thevissen D, Secchi A, Keymeulen B, Pipeleers D, Piemonti L. Transplantation. 2011 Oct 15; 92(7): 815-21.

Diabetes Antibody Standardization Program: First evaluation of assays for autoantibodies to IA-2β, Schlosser M, Mueller PW, Achenbach P, Lampasona V, Bingley PJ; Participating Laboratories. Diabetes Care. 2011 Nov; 34(11): 2410-2. Epub 2011 Sep 16.

Human enterovirus infections in children at increased risk for type 1 diabetes: the Babydiet study, Simonen-Tikka ML, Pflueger M, Klemola P, Savolainen-Kopra C, Smura T, Hummel S, Kaijalainen S, Nuutila K, Natri O, Roivainen M, Ziegler AG. Diabetologia. 2011 Dec; 54(12): 2995-3002. Epub 2011 Sep 20.

Diabetes antibody standardization program: first proficiency evaluation of assays for autoantibodies to zinc transporter 8, Lampasona V, Schlosser M, Mueller PW, Williams AJ, Wenzlau JM, Hutton JC, Achenbach P; Participating Laboratories. Clin Chem. 2011 Dec; 57(12): 1693-702. Epub 2011 Oct 6.

Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes, Ferraro A, Socci C, Stabilini A, Valle A, Monti P, Piemonti L, Nano R, Olek S, Maffi P, Scavini M, Secchi A, Staudacher C, Bonifacio E, Battaglia M. Diabetes. 2011 Nov;60(11):2903-13. Epub 2011 Sep 6.

A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes, Vaziri-Sani F, Delli AJ, Elding-Larsson H, Lindblad B, Carlsson A, Forsander G, Ivarsson SA, Ludvigsson J, Marcus C, Lernmark Å. J Immunol Methods. 2011 Aug 31; 371(1-2): 25-37. Epub 2011 Jun 25.

The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes, Andersson C, Larsson K, Vaziri-Sani F, Lynch K, Carlsson A, Cedervall E, Jönsson B, Neiderud J, Månsson M, Nilsson A, Lernmark A, Elding Larsson H, Ivarsson SA. Autoimmunity. 2011 Aug;44 (5): 394-405. doi: 10.3109/08916934.2010.540604. Epub 2011 Jan 19.

Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes, Nielsen LB, Vaziri-Sani F, Pörksen S, Andersen ML, Svensson J, Bergholdt R, Pociot F, Hougaard P, de Beaufort C, Castaño L, Mortensen HB, Lernmark A, Hansen L; Hvidoere Study Group on Childhood Diabetes. Autoimmunity. 2011 Dec; 44(8): 616-23. Epub 2011 May 23.

Vaccination against type 1 diabetes, Larsson HE, Lernmark Å, J Intern Med. 2011 Jun;269(6):626-35. doi: 10.1111/j.1365-2796.2011.02386.x.

Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain, Selivanov VA, Votyakova TV, Pivtoraiko VN, Zeak J, Sukhomlin T, Trucco M, Roca J, Cascante M. PLoS Comput Biol. 2011 Mar; 7(3): e1001115. Epub 2011 Mar 31.

Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children, Ziegler AG, Pflueger M, Winkler C, Achenbach P, Akolkar B, Krischer JP, Bonifacio E. J Autoimmun. 2011 Aug;37(1):3-7. Epub 2011 Mar 3.

Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro, Skog O, Korsgren O, Frisk G, J Med Virol. 2011 Apr;83(4):658-64. doi: 10.1002/jmv.21924.

An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes, Winkler C, Lauber C, Adler K, Grallert H, Illig T, Ziegler AG, Bonifacio E. Diabetes. 2011 Feb; 60(2): 685-90.

2010

Znt8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset, Vaziri-Sani F, Oak S, Radtke J, Lernmark A, Lynch K, Agardh CD, Cilio CM, Lethagen AL, Ortqvist E, Landin-Olsson M, Törn C, Hampe CS. Autoimmunity 2010 Dec;43(8): 598-606. Epub 2010 Mar 19.

A simplified method to assess affinity of insulin autoantibodies, Achenbach P, Guo LH, Gick C, Adler K, Krause S, Bonifacio E, Colman PG, Ziegler AG. Clin Immunol. 2010 Dec; 137(3): 415-21.

Cellular tropism of human enterovirus D species serotypes EV-94, EV-70, and EV-68 in vitro: implications for pathogenesis, Smura T, Ylipaasto P, Klemola P, Kaijalainen S, Kyllönen L, Sordi V, Piemonti L, Roivainen M. J Med Virol. 2010 Nov; 82(11): 1940-9.

Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis, Selivanov VA, Vizán P, Mollinedo F, Fan TW, Lee PW, Cascante M. BMC Syst Biol. 2010 Oct 6; 4:135.

Virus infections and type 1 diabetes risk, Roivainen M, Klingel K, Curr Diab Rep,  2010 Oct; 10 (5): 350-6.

Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes, Brorsson C, Vaziri-Sani F, Bergholdt R, Eising S, Nilsson A, Svensson J, Lernmark Å, Pociot F; Danish Study Group of Childhood Diabetes. Autoimmunity. 2011 Mar; 44(2): 107-14. Epub 2010 Sep 14.

Advances in the prediction and natural history of type 1 diabetes, Bonifacio E, Ziegler AG, Endocrinol Metab Clin North Am, 2010 Sep; 39(3): 513-25.

Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes, Lipponen K, Gombos Z, Kiviniemi M, Siljander H, Lempainen J, Hermann R, Veijola R, Simell O, Knip M, Ilonen J, Diabetes. 2010 Dec; 59(12): 3253-6. 

Mesenchymal stem cells as feeder cells for pancreatic islet transplants, Sordi V, Piemonti L, Rev Diabet Stud. 2010 Summer;7(2):132-43. Epub 2010 Aug 10.

High-titer GAD65 autoantibodies detected in adult diabetes patients using a high efficiency expression vector and cold GAD65 displacement, Hansson I, Lynch KF, Hallmans G, Lernmark Å, Rolandsson O. Autoimmunity. 2011 Mar; 44(2): 129-36. Epub 2010 Jul 29.

Enterovirus markers and serum CXCL10 in children with type 1 diabetes, Berg AK, Tuvemo T, Frisk G, J Med Virol. 2010 Sep;82(9):1594-9.

Ahmed, J et al. "Chapter 9: Type 1 Diabetes - Autoimmune type 1 diabetes." Textbook of Diabetes. 4th ed. Ed. Richard Holt et al. Chichester, UK: Wiley-Blackwell, 2010. 

Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia, Bonifacio E, Yu L, Williams AK, Eisenbarth GS, Bingley PJ, Marcovina SM, Adler K, Ziegler AG, Mueller PW, Schatz DA, Krischer JP, Steffes MW, Akolkar B. J Clin Endocrinol Metab. 2010 Jul; 95(7): 3360-7. Epub 2010 May 5.

Larson, HE et al. "Chapter 59: Future drug treatment of type 1 diabetes." Textbook of Diabetes. 4th ed. Ed. Richard Holt et al. Chichester, UK: Wiley-Blackwell, 2010. 

Role of CCL2/MCP-1 in islet transplantation, Melzi R, Mercalli A, Sordi V, Cantarelli E, Nano R, Maffi P, Sitia G, Guidotti LG, Secchi A, Bonifacio E, Piemonti L. Cell Transplant. 2010; 19(8): 1031-46. Epub 2010 Jun 11.

Enhancing the understanding of pre-type 1 diabetes in the general population,  Simell O, Winter WE, Schatz D, Diabetes Care, 2010 Jun; 33 (6):1403-5.

Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice, Melzi R, Antonioli B, Mercalli A, Battaglia M, Valle A, Pluchino S, Galli R, Sordi V, Bosi E, Martino G, Bonifacio E, Doglioni C, Piemonti L. PLoS One. 2010 Apr 27; 5(4): e10357.

Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling, Elo LL, Mykkänen J, Nikula T, Järvenpää H, Simell S, Aittokallio T, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O, Lahesmaa R. J Autoimmun. 2010 Aug; 35(1): 70-6. Epub 2010 Mar 30.

Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies, Delli AJ, Lindblad B, Carlsson A, Forsander G, Ivarsson SA, Ludvigsson J, Marcus C, Lernmark A; Better Diabetes Diagnosis (BDD) Study Group. Pediatr Diabetes. 2010 Dec; 11(8): 513-20. doi: 10.1111/j.1399-5448.2010.00637.x.

Immunology of beta-cell destruction, La Torre D, Lernmark A, Adv Exp Med Biol. 2010; 654: 537-83.

Age at development of type 1 diabetes- and celiac disease-associated antibodies and clinical disease in genetically susceptible children observed from birth, Simell S, Hoppu S, Simell T, Ståhlberg MR, Viander M, Routi T, Simell V, Veijola R, Ilonen J, Hyöty H, Knip M, Simell O. Diabetes Care. 2010 Apr; 33(4): 774-9. Epub 2010 Jan 7.

2009

Bistability of Mitochondrial Respiration Underlies Paradoxical Reactive Oxygen Species Generation Induced by Anoxia, Vitaly A. Selivanov, Tatyana V. Votyakova, Jennifer A. Zeak, Massimo Trucco, Josep Roca, Marta Cascante. PloS Computational Biology (2009) Dec;12:e1000619

Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function, Sordi V, Melzi R, Mercalli A, Formicola R, Doglioni C; Tiboni F, Ferrari G, Nano R, Chwalek K, Lammert E, Bonifacio E,  Piemonti L. Stem Cell (2009) Epub Nov. 18.

Beta-cells at the crossroads: choosing between insulin granule production and proliferation, Liu Y, Mziaut H, Ivanova A, Solimena M. Diabetes Obes Metab. (2009) Nov;11 Suppl 4:54-64

Detection of  molecular paths associated with insulitis and type 1 diabetes in non-obese diabetic mice, Lindfors E, Gopalacharyulu PV, Halperin E, Oresic M, PLoS ONE (2009) Oct;4(10):e7323

Detection of molecular paths associated with insulitis and type 1 diabetes in non-obese diabetic mouse, Lindfors E, Gopalacharyulu PV, Halperin E, Oresic M, PLoS One. 2009 Oct 2; 4 (10): e7323.

Bone marrow as an alternative site for islet transplantation, Cantarelli E, Melzi R, Mercalli A, Sordi V, Ferrari G, Lederer CW, Mrak E, Rubinacci A, Ponzoni M, Sitia G, Guidotti LG, Bonifacio E, Piemonti L. Blood (2009) Epub Sep. 22.

Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population, Siljander HT, Simell S, Hekkala A, Lähde J, Simell T, Vähäsalo P, Veijola R, Ilonen J, Simell O, Knip M. Diabetes. 2009 Dec;58(12):2835-42. Epub 2009 Sep 15.

Antiviral effect of nicotinamide on enterovirus-infected human islets in vitro: effect on virus replication and chemokine secretion, Moëll A, Skog O, Ahlin E, Korsgren O, Frisk G J. Med. Vir. (2009). Jun; 81(6): 1082-7.  

Rapamycin does not adversely affect intrahepatic islet engraftment in mice and improves early islet engraftment in humans, Melzi R, Maffi P, Nano R, Sordi V, Mercalli A, Scavini M, Secchi A, Bonifacio E, Piemonti L. Islets. 2009 Jul-Aug; 1(1): 42-9.

Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk, Achenbach P, Lampasona V, Landherr U, Koczwara K, Krause S, Grallert H, Winkler C, Pflüger M, Illig T, Bonifacio E, Ziegler AG. Diabetologia (2009) Sep;52:1881-1888

2008

Ghrelin-producing epsilon cells in the developing and adult human pancreas, Andralojc KM, Mercalli A, Nowak KW, Albarello L, Calcagno R, Luzi L, Bonifacio E, Doglioni C, Piemonti L. Diabetologia (2009) Mar;52(3):486-93.

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes, Orešič M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T, Parikka V, Katajamaa M, Hekkala A, Mattila I, Keskinen P, Yetukuri L, Reinikainen A, Lähde J, Suortti T, Hakalax J, Simell T, Hyöty H, Veijola R, Ilonen J, Lahesmaa R, Knip M, Simell O, J. Exp. Med. (2008), 13:2975-2984